SALIVARY PH VARIATION IN CHRONIC PERIODONTITIS TREATED WITH ALOE VERA VERSUS CONVENTIONAL THERAPY: A LONGITUDINAL QUASI-EXPERIMENTAL STUDY
DOI:
https://doi.org/10.64668/rccss.v2i23658Keywords:
Saliva, Hydrogen-Ion Concentration, Aloe, PeriodontitisAbstract
Objective: To determine the efficacy of Aloe vera gel as an adjunct to non-surgical periodontal therapy in regulating salivary pH and improving clinical parameters, comparing its effect against conventional treatment and mechanical therapy alone in adult patients with periodontitis. Materials and Methods: A quasi-experimental, longitudinal, and prospective clinical trial was conducted on 46 adult patients diagnosed with periodontitis. The sample was distributed into three study groups: Experimental (SRP + Aloe vera), Active Control (SRP + conventional toothpaste), and Passive Control (SRP alone). Unstimulated salivary pH was quantified using a calibrated digital pH meter at three time points: baseline, intermediate, and post-treatment. Results: An average alkaline baseline pH of 7.58 was recorded, confirming the association between alkalinity and active disease. Upon completion of therapy, the pH significantly decreased to an overall average of 7.28 (p=0.0002), reaching physiological neutrality levels. The group treated with Aloe vera exhibited pH stabilization and clinical improvement comparable to the controls, demonstrating therapeutic non-inferiority. Conclusion: Non-surgical periodontal therapy effectively restores salivary acid-base balance. Aloe vera is confirmed as a robust phytotherapeutic adjunct, capable of normalizing pH and controlling inflammation with the same competence as traditional chemical agents, offering a biocompatible alternative for the comprehensive management of periodontitis.
References
1. Meimandi M, Talebi Ardakani MR, Esmaeil Nejad A, Yousefnejad P, Saebi K, Tayeed MH. The Effect of Photodynamic Therapy in the Treatment of Chronic Periodontitis: A Review of Literature. J Lasers Med Sci. 2017;8(Suppl 1):S7-S11. Disponible en: DOI: 10.15171/jlms.2017.s2
2. Korkmaz FM, Ozel MB, Tuzuner T, Korkmaz B, Yayli N. Antimicrobial activity and volatile constituent analysis of three commercial herbal toothpastes containing Aloe vera L. and Fragaria vesca L. extracts. Niger J Clin Pract. 2019;22(5):718-726. Disponible en: DOI: 10.4103/njcp.njcp_557_18
3. Nandlal B, Sreenivasan PK, Shashikumar P, Devishree G, Bettahalli Shivamallu A. A randomized clinical study to examine the oral hygiene efficacy of a novel herbal toothpaste with zinc over a 6-month period. Int J Dent Hyg. 2021;19(4):440-449. Disponible en: DOI: 10.1111/idh.12505
4. Demir S, Keskin G, Akal N, Zer Y. Antimicrobial effect of natural kinds of toothpaste on oral pathogenic bacteria. J Infect Dev Ctries. 2021;15(10):1436-1442. Disponible en: DOI: 10.3855/jidc.14966
5. Vajrabhaya LO, Korsuwannawong S, Ruangsawasdi N, Phruksaniyom C, Srichan R. The efficiency of natural wound healing and bacterial biofilm inhibition of Aloe vera and Sodium Chloride toothpaste preparation. BMC Complement Med Ther. 2022;22(1):66. Disponible en: DOI: 10.1186/s12906-022-03548-7
6. Mazur M, Ndokaj A, Bietolini S, Nisii V, Duś-Ilnicka I, Ottolenghi L. Green dentistry: Organic toothpaste formulations. A literature review. Dent Med Probl. 2022;59(3):461-474. Disponible en: DOI: 10.17219/dmp/146133
7. Kanouté A, Dieng SN, Diop M, Dieng A, Sene AK, Diouf M, et al. Pasta dental química vs. natural: ¿Qué fórmulas para qué propiedades? Un análisis exploratorio. J Public Health Afr. 2024;13(3):a421. Disponible en: DOI: https://doi.org/10.4081/jphia.2022.1945
8. Oluwasina OO, Idris SO, Ogidi CO, Igbe FO. Production of herbal toothpaste: Physical, organoleptic, phyto-compound, and antimicrobial properties. Heliyon. 2023;9(3):e13892. Disponible en: DOI: 10.1016/j.heliyon.2023.e13892
9. Vitiello F, Monterubbianesi R, Sparabombe S, Bourgeois D, Tosco V, Alshehri FA, et al. Use of over-the-counter mouthwashes as an additional measure in individual oral prophylaxis on adults with plaque-induced gingivitis: a double-blind, parallel, randomized controlled trial. BMC Oral Health. 2024;24(1):83. Disponible en: DOI: 10.1186/s12903-023-03779-1
10. Butera A, Gallo S, Pascadopoli M, Taccardi D, Scribante A. Home Oral Care of Periodontal Patients Using Antimicrobial Gel with Postbiotics, Lactoferrin, and Aloe Barbadensis Leaf Juice Powder vs. Conventional Chlorhexidine Gel: A Split-Mouth Randomized Clinical Trial. Antibiotics. 2022;11(1):118. Disponible en: https://doi.org/10.3390/antibiotics11010118
11. Patel RM, Varma S, Suragimath G, Zope S. Estimation and Comparison of Salivary Calcium, Phosphorous, Alkaline Phosphatase and pH Levels in Periodontal Health and Disease: A Cross-sectional Biochemical Study. J Clin Diagn Res. 2016;10(7):ZC58-61. Disponible en: DOI: 10.7860/JCDR/2016/20973.8182
12. Batista JA, Wakayama B, Freitas RN, Fiais GA, Chaves-Neto AH, Saliba TA, et al. Impact of oral conditions on salivary biochemical parameters in individuals with substance use disorder: a cross-sectional study. Braz Oral Res. 2025;39:e053. Disponible en: DOI: 10.1590/1807-3107bor-2025.vol39.053
13. Kanouté A, Dieng SN, Diop M, Dieng A, Sene AK, Diouf M, Lo CM, Faye D, Carrouel F. Chemical vs. natural toothpaste: which formulas for which properties? A scoping review. J Public Health Afr. 2022 Sep 21;13(3):1945. Disponible en: DOI: 10.4081/jphia.2022.1945
14. Yaghini J, Khashei S, Afshari Z, Mogharehabed A. Evaluation of salivary calcium, phosphorus and alkaline phosphatase concentrations before and after the first phase of periodontal treatment in patients with chronic periodontitis. J Adv Periodontol Implant Dent. 2019;12(2):59-63. Disponible en: DOI: 10.34172/japid.2020.012
15. Acquier AB, Pita AK, Busch L, Sánchez GA. Comparison of salivary levels of mucin and amylase and their relation with clinical parameters obtained from patients with aggressive and chronic periodontal disease. J Appl Oral Sci. 2015;23(3):288-94. Disponible en: DOI: 10.1590/1678-775720140458
16. Jeyasree RM, Theyagarajan R, Sekhar V, Navakumar M, Mani E, Santhamurthy C. Evaluation of serum and salivary alkaline phosphatase levels in chronic periodontitis patients before and after nonsurgical periodontal therapy. J Indian Soc Periodontol. 2018;22(6):487-491. Disponible en: DOI: 10.4103/jisp.jisp_133_18
17. Parihar S, Singh P, Srivastava R, Srivastava A, Imran F, Vishnu JP. Comparative evaluation of salivary, serum, and GCF alkaline phosphatase levels in chronic periodontitis patients before and after nonsurgical periodontal therapy: A clinico-biochemical study. Natl J Maxillofac Surg. 2024;15(2):262-267. Disponible en: DOI: 10.4103/njms.njms_53_23
18. Arzani V, Soleimani M, Fritsch T, Jacob UM, Calabrese V, Arzani A. Plant polyphenols, terpenes, and terpenoids in oral health. Open Med (Wars). 2025;20(1):20251183. Disponible en: DOI: 10.1515/med-2025-1183
19. Mani E, Nirmala I, Sivasankar P, Saketharaman P, Pannnerselvam S, Priyanka L. Salivary Amylase and Mucin in Chronic Periodontitis: Pre- /Posttherapy. J Contemp Dent Pract. 2023;24(10):813-817. Disponible en: DOI: 10.5005/jp-journals-10024-3549
20. Vishnu JP, Gautam A, Mishra SP, Durrani F, Imran F, Kumari E. Comparative evaluation of mucin and total protein in periodontal disease before and after nonsurgical periodontal therapy. J Indian Soc Periodontol. 2024;28(1):84-90. Disponible en: DOI: 10.4103/jisp.jisp_258_23




